Show simple item record

dc.contributor.authorGama, Clarissa Severinopt_BR
dc.contributor.authorKunz, Mauríciopt_BR
dc.contributor.authorMagalhães, Pedro Vieira da Silvapt_BR
dc.contributor.authorKapczinski, Flávio Pereirapt_BR
dc.date.accessioned2015-03-04T01:57:57Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn1516-4446pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/111609pt_BR
dc.description.abstractIntroduction: The use of clinical staging models is emerging as a novel and useful paradigm for diagnosing severe mental disorders. The term “neuroprogression” has been used to define the pathological reorganization of the central nervous system along the course of severe mental disorders. In bipolar disorder (BD), neural substrate reactivity is changed by repeated mood episodes, promoting a brain rewiring that leads to an increased vulnerability to life stress. Method: A search in the PubMed database was performed with the following terms: “staging”, “neuroprogression”, “serum”, “plasma”, “blood”, “neuroimaging”, “PET scan”, “fMRI”, “neurotrophins”, “inflammatory markers” and “oxidative stress markers”, which were individually crossed with “cognition”, “functionality”, “response to treatments” and “bipolar disorder”. The inclusion criteria comprised original papers in the English language. Abstracts from scientific meetings were not included. Results: We divided the results according to the available evidence of serum biomarkers as potential mediators of neuroprogression, with brain imaging, cognition, functioning and response to treatments considered as consequences. Conclusion: The challenge in BD treatment is translating the knowledge of neuronal plasticity and neurobiology into clinical practice. Neuroprogression and staging can have important clinical implications, given that early and late stages of the disorder appear to present different biological features and therefore may require different treatment strategies.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofRevista brasileira de psiquiatria (1999). São Paulo. Vol. 35, n. 1 (mar. 2013), p. 70-74pt_BR
dc.rightsOpen Accessen
dc.subjectBipolar disorderen
dc.subjectTranstorno bipolarpt_BR
dc.subjectProgressão da doençapt_BR
dc.subjectClinical responseen
dc.subjectNeuroimagempt_BR
dc.subjectNeuroimagingen
dc.subjectNeuroprogressionen
dc.subjectSerum Biomarkersen
dc.subjectStagingen
dc.titleStaging and neuroprogression in bipolar disorder : a systematic review of the literaturept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000945730pt_BR
dc.type.originNacionalpt_BR


Files in this item

Thumbnail
   

This item is licensed under a Creative Commons License

Show simple item record