Browsing Biological Sciences by Author "Vainstein, Marilene Henning"
Now showing items 21-37 of 37
-
Nanoemulsion improves the antifungal activity of allylic thiocyanates against yeasts and filamentous pathogenic fungi
(2018) [Journal article]We report the antifungal and antichemotactic activities of a series of allylic thiocyanates with low toxicity. We also show improved antifungal activity of the most promising compound when used in a nanoemulsion (NE). The ... -
A novel protocol for the isolation of fungal extracellular vesicles reveals the participation of a putative scramblase in polysaccharide export and capsule construction in Cryptococcus gattii
(2019) [Journal article]Regular protocols for the isolation of fungal extracellular vesicles (EVs) are time-consuming, hard to reproduce, and produce low yields. In an attempt to improve the protocols used for EV isolation, we explored a model ... -
Optimal conditions for continuous immobilization of Pseudozyma hubeiensis (Strain HB85A) lipase by adsorption in a packed-bed reactor by response surface methodology
(2012) [Journal article]This study aimed to develop an optimal continuous process for lipase immobilization in a bed reactor in order to investigate the possibility of large-scale production. An extracellular lipase of Pseudozyma hubeiensis (strain ... -
Pathogenic diversity amongst serotype C VGIII and VGIV Cryptococcus gattii isolates
(2015) [Journal article] -
A plumieridine-rich fraction from Allamanda polyantha inhibits chitinolytic activity and exhibits antifungal properties against Cryptococcus neoformans
(2020) [Journal article]Cryptococcosis is a fungal infection caused mainly by the pathogenic yeasts Cryptococcus neoformans and Cryptococcus gattii. The infection initiates with the inhalation of propagules that are then deposited in the lungs. ... -
A potential source for cellulolytic enzyme discovery and environmental aspects revealed through metagenomics of brazilian mangroves
(2013) [Journal article]The mangroves are among the most productive and biologically important environments. The possible presence of cellulolytic enzymes and microorganisms useful for biomass degradation as well as taxonomic and functional aspects ... -
Scaffold repositioning of spiro-acridine derivatives as fungi chitinase inhibitor by target fishing and in vitro studies
(2023) [Journal article]The concept of “one target, one drug, one disease” is not always true, as compounds with previously described therapeutic applications can be useful to treat other maladies. For example, acridine derivatives have several ... -
Scanning electron microscopy and machine learning reveal heterogeneity in capsular morphotypes of the human pathogen Cryptococcus spp.
(2020) [Journal article]Phenotypic heterogeneity is an important trait for the development and survival of many microorganisms including the yeast Cryptococcus spp., a deadly pathogen spread worldwide. Here, we have applied scanning electron ... -
Secondary metabolite gene clusters in the entomopathogen fungus Metarhizium anisopliae : genome identification and patterns of expression in a cuticle infection model
(2016) [Journal article]Background: The described species from the Metarhizium genus are cosmopolitan fungi that infect arthropod hosts. Interestingly, while some species infect a wide range of hosts (host-generalists), other species infect only ... -
Susceptibility to heat and antifungal agents of Cryptococcus neoformans var. neoformans (Serotype D) isolated from Eucalyptus spp in Rio Grande do Sul, Brazil
(2005) [Journal article]Este estudo foi realizado com os primeiros isolados ambientais de C. neoformans sorotipo D, obtidos no Rio Grande Susceptibility of C. neoformans to heat and antifungal agents 5 do Sul. Objetivando-se avaliar a susceptibilidade ... -
The homeostasis of iron, copper, and zinc in Paracoccidioides brasiliensis, Cryptococcus neoformans var. grubii, and Cryptococcus gattii : a comparative analysis
(2011) [Journal article]Iron, copper, and zinc are essential for all living organisms. Moreover, the homeostasis of these metals is vital to microorganisms during pathogenic interactions with a host. Most pathogens have developed specific mechanisms ... -
The vacuolar-sorting protein Snf7 is required for export of virulence determinants in members of the Cryptococcus neoformans complex
(2014) [Journal article]Fungal pathogenesis requires a number of extracellularly released virulence factors. Recent studies demonstrating that most fungal extracellular molecules lack secretory tags suggest that unconventional secretion mechanisms ... -
Transcriptional analysis allows genome reannotation and reveals that Cryptococcus gattii VGII undergoes nutrient restriction during infection
(2017) [Journal article]Cryptococcus gattii is a human and animal pathogen that infects healthy hosts and caused the Pacific Northwest outbreak of cryptococcosis. The inhalation of infectious propagules can lead to internalization of cryptococcal ... -
Transcriptomic analysis reveals that mTOR pathway can be modulated in macrophage cells by the presence of cryptococcal cells
(2021) [Journal article]Cryptococcus neoformans and Cryptococcus gattii are the etiological agents of cryptococcosis, a high mortality disease. The development of such disease depends on the interaction of fungal cells with macrophages, in which ... -
Virulence factors and antimicrobial resistance of escherichia coli isolated from urinary tract of swine in southern of Brazil
(2008) [Journal article]The present study determined the molecular and resistance patterns of E. coli isolates from urinary tract of swine in Southern of Brazil. Molecular characterization of urinary vesicle samples was performed by PCR detection ... -
Virulence factors, antimicrobial resistance, and plasmid content of Escherichia coli isolated in swine commercial farms
(2010) [Journal article]Os fatores de virulência e a resistência aos antimicrobianos foram avaliados em Escherichia coli. Um total de 80 isolados de E. coli, sendo 64 de amostras clínicas (conteúdo intestinal e fragmentos de órgãos de leitões ... -
Zap1 regulates zinc homeostasis and modulates virulence in Cryptococcus gattii
(2012) [Journal article]Zinc homeostasis is essential for fungal growth, as this metal is a critical structural component of several proteins, including transcription factors. The fungal pathogen Cryptococcus gattii obtains zinc from the stringent ...
