Now showing items 1-18 of 18

    • Antimicrobial activity and phytochemical screening of buchenavia tetraphylla (aubl.) R. A. Howard (combretaceae: combretoideae) 

      Oliveira, Ygor Lucena Cabral de; Silva, Luís Cláudio Nascimento da; Silva, Alexandre Gomes da; Macedo, Alexandre José; Araújo, Janete Magali; Correia, Maria Tereza dos Santos; Silva, Márcia Vanusa da (2012) [Journal article]
      This study evaluated the antimicrobial and hemolytic activities and phytochemical constituents of hydroalcoholic extract and its fractions from Buchenavia tetraphylla leaves. Cyclohexane (BTCF), ethyl acetate (BTEF), and ...
    • Enzimas microbianas de uso terapêutico e diagnóstico clínico 

      Zimmer, Karine Rigon; Borré, Gustavo Luís; Trentin, Danielle da Silva; Woicickoski Júnior, Clóvis; Frasson, Amanda Piccoli; Graeff, Alexandre de Arruda; Gomes, Patricia; Macedo, Alexandre José (2009) [Journal article]
      Enzimas microbianas têm se destacado como um dos principais produtos tecnológicos do mundo moderno, porém seu uso tem relatos nos tempos mais remotos. No início do século XX, teve início a produção em grande escala de ...
    • Estratégias e desafios no combate à malária 

      Frasson, Amanda Piccoli; Barlette, Adriana Gregory; Dalpizolo, Cristiano; Sauter, Ismael Pretto; Macedo, Alexandre José; Tasca, Tiana (2009) [Journal article]
      A malária é uma das mais importantes doenças parasitárias do mundo, apresentando como agente etiológico protozoários do gênero Plasmodium. Dados recentes apontam que aproximadamente 40% da população mundial está exposta à ...
    • Evaluation of antibiotics as a methodological procedure to inhibit free-living and biofilm bacteria in marine zooplankton culture 

      Agostini, Vanessa Ochi; Macedo, Alexandre José; Muxagata, Erik (2016) [Journal article]
      There is a problem with keeping culture medium completely or partially free from bacteria. The use of prokaryotic metabolic inhibitors, such as antibiotics, is suggested as an alternative solution, although such substances ...
    • High vancomycin resistance among biofilms produced by staphylococcus species isolated from central venous catheters 

      Antunes, Ana Lucia Souza; Bonfanti, Jéssica Weis; Perez, Leandro Reus Rodrigues; Pinto, Camille Catani Ferreira; Freitas, Ana Lucia Peixoto de; Macedo, Alexandre José; Barth, Afonso Luis (2011) [Journal article]
      Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. ...
    • Intestinal parasitism and socio-environmental factors among mbyá-guarani indians, Porto Alegre, Rio Grande do Sul, Brazil 

      Brandelli, Clara Lia Costa; De Carli, Geraldo Attilio; Macedo, Alexandre José; Tasca, Tiana (2012) [Journal article]
      Dados preocupantes demonstram a prevalência de parasitos intestinais e sua relação com fatores socioambientais entre indígenas Mbya-Guarani. A prevalência foi determinada pelas técnicas de sedimentação espontânea em água, ...
    • Iron from haemoglobin and haemin modulates nucleotide hydrolysis in Trichomonas vaginalis 

      Vieira, Patrícia de Brum; Silva, Nícolas Luiz Feijó; Kist, Luiza Wilges; Oliveira, Giovanna Medeiros Tavares de; Bogo, Mauricio Reis; Carli, Geraldo Attilio de; Macedo, Alexandre José; Tasca, Tiana (2015) [Journal article]
      Extracellular ATP may act as a danger signalling molecule, inducing inflammation and immune responses in infection sites. The ectonucleotidases NTPDase and ecto-5’-nucleotidase are enzymes that modulate extracellular ...
    • Macrocolony of NDM-1 producing Enterobacter hormaechei subsp. oharae generates subpopulations with different features regarding the response of antimicrobial agents and biofilm formation 

      Brust, Flavia Roberta; Boff, Luana; Trentin, Danielle da Silva; Rozales, Franciéli Pedrotti; Barth, Afonso Luis; Macedo, Alexandre José (2019) [Journal article]
      Enterobacter cloacae complex has been increasingly recognized as a nosocomial pathogen representing the third major Enterobacteriaceae species involved with infections. This study aims to evaluate virulence and antimicrobial ...
    • Microrganismos em favor da saúde humana 

      Carvalho, Maira Peres de; Abraham, Wolf Rainer; Macedo, Alexandre José (2008) [Journal article]
      Os fungos e as bactérias possuem um enorme potencial de produção de compostos biologicamente ativos que podem e são utilizados no tratamento de várias enfermidades humanas. Destaca-se, nesta breve revisão, a importância ...
    • Modulatory effect of iron chelators on adenosine deaminase activity and gene expression in Trichomonas vaginalis 

      Barros, Muriel Primon de; Rigo, Graziela de Vargas; Frasson, Amanda Piccoli; Santos, Odelta dos; Smiderle, Lisiane; Almeida, Silvana Maria de; Macedo, Alexandre José; Tasca, Tiana (2015) [Journal article]
      Trichomonas vaginalis is a flagellate protozoan that parasitises the urogenital human tract and causes trichomoniasis. During the infection, the acquisition of nutrients, such as iron and purine and pyrimidine nucleosides, ...
    • Myricetin protects Galleria mellonella against Staphylococcus aureus infection and inhibits multiple virulence factors 

      Silva, Laura Nunes; Hora, Gabriel Costa Alverni da; Silva, Thereza Amélia Soares da; Bojer, Martin Saxtorph; Ingmer, Hanne; Macedo, Alexandre José; Trentin, Danielle da Silva (2017) [Journal article]
      Staphylococcus aureus is an opportunistic pathogen related to a variety of life-threatening infections but for which antimicrobial resistance is liming the treatment options. We report here that myricetin, but not its ...
    • Optimal reference genes for gene expression normalization in Trichomonas vaginalis 

      Santos, Odelta dos; Rigo, Graziela de Vargas; Frasson, Amanda Piccoli; Macedo, Alexandre José; Tasca, Tiana (2015) [Journal article]
      Trichomonas vaginalis is the etiologic agent of trichomonosis, the most common non-viral sexually transmitted disease worldwide. This infection is associated with several health consequences, including cervical and prostate ...
    • Pharmacological properties of specioside from the stem bark of Tabebuia aurea 

      Nocchi, Samara Requena; Kato, Natália Naomi; Almeida, Júlio Menta de; Ferreira, Alda Maria Teixeira; Kadri, Mônica Cristina Toffoli; Meirelles, Lyvia Eloiza de Freitas; Damke, Gabrielle Marconi Zago Ferreira; Consolaro, Márcia Edilaine Lopes; Rigo, Graziela de Vargas; Macedo, Alexandre José; Tasca, Tiana; Reis, Sharon Vieira dos; Alves, Flávio Macedo; Carollo, Carlos Alexandre; Silva, Denise Brentan (2020) [Journal article]
      Iridoids are secondary metabolites with several biological activities. They are often found in species of the genus Tabebuia Gomes ex A.P. de Candolle. Tabebuia aurea (Silva Manso) Benth. & Hook. F. ex S. Moore, Bignoniaceae, ...
    • Pseudonajide peptide derived from snake venom alters cell envelope integrity interfering on biofilm formation in Staphylococcus epidermidis 

      Schneider, Rafael de Oliveira; Barros, Muriel Primon de; Von Borowski, Rafael Gomes; Chat, Sophie; Nonin-Lecomte, Sylvie; Gillet, Reynald; Macedo, Alexandre José (2020) [Journal article]
      Background: The increase in bacterial resistance phenotype cases is a global health problem. New strategies must be explored by the scientific community in order to create new treatment alternatives. Animal venoms are a ...
    • Remarkable anti-trichomonas vaginalis activity of plants traditionally used by the MbYá-guarani indigenous group in Brazil 

      Brandelli, Clara Lia Costa; Vieira, Patrícia de Brum; Macedo, Alexandre José; Tasca, Tiana (2013) [Journal article]
      Trichomonas vaginalis, a flagellate protozoan, is the causative agent of trichomonosis, the most common nonviral sexually transmitted disease worldwide. Taking into account the increased prevalence of metronidazole-resistant ...
    • Resistência bacteriana no meio ambiente e implicações na clínica hospitalar 

      Caumo, Karin Silva; Duarte, Mariana; Cargnin, Simone Tasca; Ribeiro, Vanessa Bley; Tasca, Tiana; Macedo, Alexandre José (2010) [Journal article]
      O aumento da incidência de infecções microbianas resistentes a antibióticos adquiridas tanto na comunidade quanto nos hospitais tem chamado a atenção da comunidade de saúde. Neste contexto, muitos estudos têm demonstrado ...
    • Trichomonicidal and parasite membrane damaging activity of bidesmosic saponins from Manilkara rufula 

      Vieira, Patrícia de Brum; Silva, Nícolas Luiz Feijó; Menezes, Camila Braz; Silva, Márcia Vanusa da; Silva, Denise Brentan; Lopes, Norberto Peporine; Macedo, Alexandre José; Bastida, Jaume; Tasca, Tiana (2017) [Journal article]
      The infection caused by Trichomonas vaginalis is the most common but overlooked nonviral sexually transmitted disease worldwide. Treatment relies on one class of drugs, the 5- nitroimidazoles, but resistance is widespread. ...
    • Triterpene derivatives as relevant scaffold for new antibiofilm drugs 

      Silva, Gloria Narjara Santos da; Barros, Muriel Primon de; Macedo, Alexandre José; Gnoatto, Simone Cristina Baggio (2019) [Journal article]
      New medicines for the treatment of bacterial biofilm formation are required. For this reason, this study shows the in vitro activity of betulinic acid (BA), ursolic acid (UA) and their twenty derivatives against planktonic ...