Browsing Health Sciences by Subject "Iodeto peroxidase"
Now showing items 1-10 of 10
-
Abnormal thyroid hormone status differentially affects bone mass accrual and bone strength in C3H/HeJ mice: a mouse model of type I deiodinase deficiency
(2019) [Journal article]C3H/HeJ (C3H) mice are deficient of type I deiodinase (D1), an enzyme that activates thyroid hormone (TH), converting thyroxine (T4) to triiodothyronine (T3). Nevertheless, C3H mice present normal serum T3 and a gross ... -
DIO2 (deiodinase, iodothyronine, type II)
(2011) [Journal article] -
Liraglutide activates type 2 deiodinase and enhances β3-adrenergic-induced thermogenesis in mouse adipose tissue
(2022) [Journal article]Aims: Liraglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist used as an anti-hyperglycemic agent in type 2 diabetes treatment and recently approved for obesity management. Weight loss is attributed ... -
Low inflammatory stimulus increases D2 activity and modulates thyroid hormone metabolism during myogenesis in vitro
(2022) [Journal article]Thyroid hormone (TH) signaling controls muscle progenitor cells differentiation. However, inflammation can alter muscle TH signaling by modulating the expression of TH transporters (Slc16a2), receptors (Thra1), and deiodinase ... -
Modulation of deiodinase types 2 and 3 during skeletal muscle regeneration
(2022) [Journal article]The muscle stem-cell niche comprises numerous cell types, which coordinate the regeneration process after injury. Thyroid hormones are one of the main factors that regulate genes linked to skeletal muscle. In this way, ... -
New insights toward the acute non-thyroidal illness syndrome
(2012) [Journal article]The non-thyroidal illness syndrome (NTIS) refers to changes in serum thyroid hormone levels observed in critically ill patients in the absence of hypothalamic–pituitary–thyroid primary dysfunction. Affected individuals ... -
Relationship among low T3 levels, type 3 deiodinase, oxidative stress, and mortality in sepsis and septic shock : defining patient outcomes
(2023) [Journal article]Low T3 syndrome occurs frequently in patients with sepsis. Type 3 deiodinase (DIO3) is present in immune cells, but there is no description of its presence in patients with sepsis. Here, we aimed to determine the prognostic ... -
The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistance
(2014) [Journal article]The Thr92Ala (rs225014) polymorphism in the type 2 deiodinase (DIO2) gene has been associated with insulin resistance (IR) and decreased enzyme activity in human tissues but kinetic studies failed to detect changes in the ... -
Type 2 deiodinase Thr92Ala polymorphism is not associated with cognitive impairment in older adults : a cross-sectional study
(2022) [Journal article]Background: Type 2 Deiodinase (DIO2) converts thyroxine (T4) into the active hormone triiodothyronine (T3). Thr92Ala DIO2 polymorphism has been associated with reduced conversion of T4 into T3 and central nervous system ... -
Uncovering actions of type 3 deiodinase in the metabolic dysfunction-associated fatty liver disease (MAFLD)
(2023) [Journal article]Metabolic dysfunction-associated fatty liver disease (MAFLD) has gained worldwide attention as a public health problem. Nonetheless, lack of enough mechanistic knowledge restrains effective treatments. It is known that ...
