Now showing items 1-2 of 2

    • Antitumor activities and cellular changes induced by TrkB inhibition in medulloblastoma 

      Thomaz, Amanda Cristina Godot; Pinheiro, Kelly de Vargas; Souza, Bárbara Kunzler; Gregianin, Lauro José; Brunetto, Algemir Lunardi; Brunetto, Andre Tessainer; Farias, Caroline Brunetto de; Jaeger, Mariane da Cunha; Ramaswamy, Vijay; Nor, Carolina; Taylor, Michael David; Roesler, Rafael (2019) [Journal article]
      Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that acts by binding to the tropomyosin receptor kinase B (TrkB) receptor, ...
    • Ecto-5’-nucleotidase overexpression reduces tumor growth in a xenograph medulloblastoma model 

      Cappellari, Angélica Regina; Pillat, Micheli Mainardi; De Souza, Héllio Danny Nóbrega; Dietrich, Fabrícia; Oliveira, Francine Hehn de; Figueiró, Fabrício; Abujamra, Ana Lúcia; Roesler, Rafael; Lecka, Joanna; Sevigny, Jean; Battastini, Ana Maria Oliveira; Ulrich, Henning (2015) [Journal article]
      Background Ecto-5’-nucleotidase/CD73 (ecto-5’-NT) participates in extracellular ATP catabolism by converting adenosine monophosphate (AMP) into adenosine. This enzyme affects the progression and invasiveness of different ...