Now showing items 1-5 of 5

    • Caenorhabditis elegans as an alternative in vivo model to determine oral uptake, nanotoxicity, and efficacy of melatonin-loaded lipid-core nanocapsules on paraquat damage 

      Charão, Mariele Feiffer; Souto, Caroline; Brucker, Natália; Barth, Anelise; Jornada, Denise Soledade; Fagundez, Daiandra de Almeida; Ávila, Daiana Silva de; Eifler-Lima, Vera Lucia; Guterres, Silvia Stanisçuaski; Pohlmann, Adriana Raffin; Garcia, Solange Cristina (2015) [Journal article]
      Caenorhabditis elegans is an alternative in vivo model that is being successfully used to assess the pharmacological and toxic effects of drugs. The exponential growth of nanotechnology requires the use of alternative in ...
    • Chitosan gel containing polymeric nanocapsules : a new formulation for vaginal drug delivery 

      Frank, Luiza Abrahão; Sandri, Giuseppina; D'Autilia, Francesca; Contri, Renata Vidor; Bonferoni, Maria Cristina; Caramella, Carla; Frank, Alejandro Germán; Pohlmann, Adriana Raffin; Guterres, Silvia Stanisçuaski (2014) [Journal article]
      The vaginal route of administration is an alternative for several treatments for either local or systemic pharmacological effects. However, the permanence of a drug in this route represents a challenge for formulation ...
    • Effects of two types of melatonin-loaded nanocapsules with distinct supramolecular structures : Polymeric (NC) and Lipid-Core Nanocapsules (LNC) on bovine embryo culture model 

      Komninou, Eliza Rossi; Remião, Mariana Härter; Lucas, Caroline Gomes; Domingues, William Borges; Basso, Andréa Cristina; Jornada, Denise Soledade; Deschamps, João Carlos; Beck, Ruy Carlos Ruver; Pohlmann, Adriana Raffin; Bordignon, Vilceu; Seixas, Fabiana Kömmling; Campos, Vinicius Farias; Guterres, Silvia Stanisçuaski; Collares, Tiago Veiras (2016) [Journal article]
      Melatonin has been used as a supplement in culture medium to improve the efficiency of in vitro produced mammalian embryos. Through its ability to scavenge toxic oxygen derivatives and regulate cellular mRNA levels for ...
    • Lipid-core nanocapsules : mechanism of self-assembly, control of size and loading capacity 

      Jornada, Denise Soledade; Fiel, Luana Almeida; Condotta, Kelly Bueno; Gerent, Josepe Franco; Petzhold, Cesar Liberato; Beck, Ruy Carlos Ruver; Guterres, Silvia Stanisçuaski; Pohlmann, Adriana Raffin (2012) [Journal article]
      Nanotechnology in pharmaceutics has the potential to improve drug efficacy by influencing drug distribution in tissues. Nanocarriers have been developed as drug delivery systems to be administered by different biological ...
    • Novel therapeutic mechanisms determine the effectiveness of lipid-core nanocapsules on melanoma models 

      Drewes, Carine Cristiane; Fiel, Luana Almeida; Bexiga, Celina Goulart; Asbahr, Ana Carolina Cavazzin; Uchiyama, Mayara Klimuk; Cogliati, Bruno; Araki, Koiti; Guterres, Silvia Stanisçuaski; Pohlmann, Adriana Raffin; Farsky, Sandra Helena Poliselli (2016) [Journal article]
      Melanoma is a severe metastatic skin cancer with poor prognosis and no effective treatment. Therefore, novel therapeutic approaches using nanotechnology have been proposed to improve therapeutic effectiveness. Lipid-core ...