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dc.contributor.authorSaueressig, Mauricio Guidipt_BR
dc.contributor.authorEdelweiss, Maria Isabel Albanopt_BR
dc.contributor.authorSouza, Fabiano H.pt_BR
dc.contributor.authorMoreschi, Alexandre Heitorpt_BR
dc.contributor.authorSavegnago, Fabrício L.pt_BR
dc.contributor.authorMacedo Neto, Amarilio Vieira dept_BR
dc.date.accessioned2010-04-24T04:15:38Zpt_BR
dc.date.issued2005pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21186pt_BR
dc.description.abstractAn effective preservation method and decreased rejection are essential for tracheal transplantation in the reconstruction of large airway defects. Our objective in the present study was to evaluate the antigenic properties of glycerin-preserved tracheal segments. Sixty-one tracheal segments (2.4 to 3.1 cm) were divided into three groups: autograft (N = 21), fresh allograft (N = 18) and glycerin-preserved allograft (N = 22). Two segments from different groups were implanted into the greater omentum of dogs (N = 31). After 28 days, the segments were harvested and analyzed for mononuclear infiltration score and for the presence of respiratory epithelium. The fresh allograft group presented the highest score for mononuclear infiltration (1.78 ± 0.43, P ≤ 0.001) when compared to the autograft and glycerinpreserved allograft groups. In contrast to the regenerated epithelium observed in autograft segments, all fresh allografts and glycerinpreserved allografts had desquamation of the respiratory mucosa. The low antigenicity observed in glycerin segments was probably the result of denudation of the respiratory epithelium and perhaps due to the decrease of major histocompatibility complex class II antigens.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoporpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 38, no. 7 (July 2005), p. 1071-1075.pt_BR
dc.rightsOpen Accessen
dc.subjectGraft rejectionen
dc.subjectRejeição de enxertopt_BR
dc.subjectTraquéia : Transplantept_BR
dc.subjectTracheaen
dc.subjectTransplantationen
dc.subjectTranplantept_BR
dc.subjectGlicerolpt_BR
dc.subjectGlycerolen
dc.subjectMucosa respiratóriapt_BR
dc.subjectRespiratory mucosaen
dc.titleHeterotopic transplantation of glycerin-preserved trachea : effect of respiratory epithelium desquamation on acute rejectionpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000515029pt_BR
dc.type.originNacionalpt_BR


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