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dc.contributor.authorRiffel, Alessandropt_BR
dc.contributor.authorMedina, Luis Fernando da Costapt_BR
dc.contributor.authorStefani, Valterpt_BR
dc.contributor.authorSantos, R.C.pt_BR
dc.contributor.authorBizani, Delmarpt_BR
dc.contributor.authorBrandelli, Adrianopt_BR
dc.date.accessioned2010-04-27T04:16:46Zpt_BR
dc.date.issued2002pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21273pt_BR
dc.description.abstractThe antibacterial activity of a series of 1,4-naphthoquinones was demonstrated. Disk diffusion tests were carried out against several Gram-positive and Gram-negative bacteria. The compound 5-amino- 8-hydroxy-1,4-naphthoquinone was the most effective, presenting inhibition zones measuring 20 mm against staphylococci, streptococci and bacilli at 50 μg/ml. Methicillin-resistant Staphylococcus aureus and several clinical isolates of this bacterium were also inhibited. Naphthazarin, 5-acetamido-8-hydroxy-1,4-naphthoquinone, and 2,3- diamino-1,4-naphthoquinone were the next most active compounds. The minimal inhibitory concentration of the active compounds was determined against S. aureus, ranging from 30 to 125 μg/ml. All compounds presented a minimal bactericidal concentration higher than 500 μg/ml, indicating that their effect was bacteriostatic. The EC50, defined as the drug concentration that produces 50% of maximal effect, was 8 μg/ml for 5-amino-8-hydroxy-1,4-naphthoquinone against S. aureus, S. intermedius, and S. epidermidis. These results indicate an effective in vitro activity of 5-amino-8-hydroxy-1,4-naphthoquinone and encourage further studies for its application in antibiotic therapy.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research =Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto. Vol. 35, no. 7 (jul. 2002), p. 811-818pt_BR
dc.rightsOpen Accessen
dc.subject5-Amino-8-hydroxy-1,4- naphthoquinoneen
dc.subjectNaftoquinonaspt_BR
dc.subjectAntimicrobial agenten
dc.subjectAtividade antimicrobianapt_BR
dc.subjectStaphylococcus aureusen
dc.subjectQuinoneen
dc.subjectNaphthazarinen
dc.subject5-Acetamido-8-hydroxy-1,4-naphthoquinoneen
dc.subject2,3-Diamino-1,4-naphthoquinoneen
dc.titleIn vitro antimicrobial activity of a new series of 1,4-naphthoquinonespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000327627pt_BR
dc.type.originNacionalpt_BR


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