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dc.contributor.authorBarbosa, Fábio de Souzapt_BR
dc.contributor.authorPezzi, Leonardo Caprapt_BR
dc.contributor.authorSorrentino, Julia Medeirospt_BR
dc.contributor.authorSteppe, Martinpt_BR
dc.contributor.authorVolpato, Nadia Mariapt_BR
dc.contributor.authorMendez, Andreas Sebastian Loureiropt_BR
dc.date.accessioned2020-12-19T04:19:25Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn2527-2616pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/216730pt_BR
dc.description.abstractStability studies correspond to a set of tests designed to assess changes in the quality of a given drug over time and under the influence of a number of factors. Among these factors, pH plays an important role, due to the catalytic effect that hydronium and hydroxide ions can play in several reactions. In the present study, the degradation kinetics of nitazoxanide was evaluated over a wide pH range, and the main degradation product generated was identified by LC-MS/MS. Nitazoxanide showed first-order degradation kinetics in the pH range of 0.01 to 10.0 showing greater stability between pH 1.0 and 4.0. The degradation rate constant calculated for these pH was 0.0885 x 10-2 min-1 and 0.0689 x 10-2 min-1, respectively. The highest degradation rate constant value was observed at pH 10.0 (0.7418 x 10-2 min-1) followed by pH 0.01 (0.5882 x 10-2 min-1). A major degradation product (DP-1) was observed in all conditions tested. Through LC-MS/MS analysis, DP-1 was identified as a product of nitazoxanide deacetylation. The effect of pH on the stability of nitazoxanide and the kinetic data obtained contribute to a better understanding of the intrinsic stability characteristics of nitazoxanide.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofDrug analytical research. Porto Alegre (RS). Vol. 4, n. 1 (2020), p. 12-17pt_BR
dc.rightsOpen Accessen
dc.subjectFarmáciapt_BR
dc.subjectNitazoxanideen
dc.subjectEstabilidade de medicamentospt_BR
dc.subjectSabilityen
dc.subjectKineticen
dc.subjectDegradation productsen
dc.titlepH effect on stability and kinetics degradation of nitazoxanide in solutionpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001119864pt_BR
dc.type.originNacionalpt_BR


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