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dc.contributor.authorSilva, Klerize Anecely de Souzapt_BR
dc.contributor.authorSpagnol, Fabianept_BR
dc.contributor.authorFarias, Mariela Graneropt_BR
dc.contributor.authorAlegretti, Ana Paulapt_BR
dc.contributor.authorMichalowski, Mariana Bohnspt_BR
dc.contributor.authorDaudt, Liane Estevespt_BR
dc.date.accessioned2022-01-27T04:35:02Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn2531-1379pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/234556pt_BR
dc.description.abstractBackground: The minimal residual disease (MRD) is the most important prognostic factor for acute lymphoblastic leukemia (ALL) in children. This study aimed to investigate the influence of detecting the MRD by the multiparametric flow cytometry (MFC) at day 15 (D15) of the induction on the analysis of the risk group classifications of the different childhood ALL treatment protocols used in a referral hospital in southern Brazil. Method: We retrospectively reviewed the medical records of patients with B-cell ALL, aged 1 to 18 years, treated at a hospital from January 2013 to April 2017. Main results: Seventy-five patients were analyzed. Regarding the MRD by the MFC at D15, the analyses showed statistical significance when the MRD was grouped into three categories, < 0.1%, 0.1–10%, and > 10%, with the following distribution: 30.7%, 52.0%, and 17.3%, respectively. There was a significant association between D15 MRD-MFC < 0.1% and the likelihood of dying or relapsing and between D15 MRD-MFC > 10% and the likelihood of dying or relapsing. The cumulative hazard ratio for the relapse of patients with D15 MRD-MFC < 0.1%, 0.1–10%, and > 10% was 19.2%, 59.8%, and 80.1%, respectively. Conclusion: Our analysis suggests D15 MRD-MFC < 0.1% as a cut-off point for patients with more favorable outcomes and that the MRD at D15 in risk classifications is particularly useful for the stratification of patients with a more favorable prognosis.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofHematology, transfusion and cell therapy. [Rio de Janeiro]. Vol. 42, no. 4 (2020), p. 348–355pt_BR
dc.rightsOpen Accessen
dc.subjectLeucemia-linfoma linfoblástico de células precursoraspt_BR
dc.subjectChildhood ALLen
dc.subjectRisk factorsen
dc.subjectFatores de riscopt_BR
dc.subjectPrognosisen
dc.subjectPrognósticopt_BR
dc.subjectNeoplasia residualpt_BR
dc.subjectMinimal residual diseaseen
dc.titleInfluence of minimal residual disease by multiparametric flow cytometry at day 15 of induction in risk stratification of children with B-cell acute lymphoblastic leukemia treated at a referral hospital in southern Brazilpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001135973pt_BR
dc.type.originNacionalpt_BR


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