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dc.contributor.authorGiovanetti, Martapt_BR
dc.contributor.authorCampos, Fabrício Souzapt_BR
dc.contributor.authorSantos, Cláudia Nunes Duarte dospt_BR
dc.date.accessioned2023-09-23T03:38:29Zpt_BR
dc.date.issued2023pt_BR
dc.identifier.issn2375-2548pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/265155pt_BR
dc.description.abstractDespite the considerable morbidity and mortality of yellow fever virus (YFV) infections in Brazil, our understanding of disease outbreaks is hampered by limited viral genomic data. Here, through a combination of phylogenetic and epidemiological models, we reconstructed the recent transmission history of YFV within different epidemic seasons in Brazil. A suitability index based on the highly domesticated Aedes aegypti was able to capture the seasonality of reported human infections. Spatial modeling revealed spatial hotspots with both past reporting and low vaccination coverage, which coincided with many of the largest urban centers in the Southeast. Phylodynamic analysis unraveled the circulation of three distinct lineages and provided proof of the directionality of a known spatial corridor that connects the endemic North with the extra-Amazonian basin. This study illustrates that genomics linked with eco-epidemiology can provide new insights into the landscape of YFV transmission, augmenting traditional approaches to infectious disease surveillance and control.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofScience advances. Washington, DC. Vol. 9, no. 35 (Sept. 2023), eadg9204, 12 p.pt_BR
dc.rightsOpen Accessen
dc.subjectVírus da febre amarelapt_BR
dc.subjectEpidemiologiapt_BR
dc.subjectSequenciamento por nanoporospt_BR
dc.subjectGenomapt_BR
dc.titleGenomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazilpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001177065pt_BR
dc.type.originEstrangeiropt_BR


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