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dc.contributor.authorCalil, Luciane Noalpt_BR
dc.contributor.authorIgansi, Cristine Nascentept_BR
dc.contributor.authorMeurer, Luísept_BR
dc.contributor.authorEdelweiss, Maria Isabel Albanopt_BR
dc.contributor.authorBozzetti, Mary Clarissept_BR
dc.date.accessioned2012-03-23T01:20:48Zpt_BR
dc.date.issued2011pt_BR
dc.identifier.issn1413-8670pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/37809pt_BR
dc.description.abstractThe objective of this study was to identify the frequency of coinfection by human papillomavirus (HPV) and Chlamydia trachomatis (CT) in cervical lesions and relate it with immunohistochemical expression of p16INK4a and Ki67, both oncogenicity markers. A cross-sectional study with 86 women from primary care units in southern Brazil was conducted. Cervical swabs were collected for HPV-DNA and CT-DNA detection, through the polymerase chain reaction technique (PCR). The immunohistochemical analysis was performed on biopsy cervical tissue material to identify the expression of p16INK4a and Ki67 cell cycle markers. About 83 % were positive for HPV-DNA and 19% had coinfection with CT-DNA. Among coinfected women, 56% expressed p16INK4a. There was a statistically significant association between the histological grade of the lesion and Ki67 expression. All high-grade lesions, 50% of low-grade lesions and 31% of negative biopsies expressed Ki67 (p = 0.004). A total of 37% of coinfected women expressed both markers. In conclusion, although more than half of the coinfected patients have expressed p16INK4a and more than one third have expressed both markers, these results suggest no association between those variables. However, other studies involving larger samples are necessary to corroborate such findings.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofThe Brazilian journal of infectious diseases. Vol. 15, n. 2 (Mar./Apr. 2011), p. 126-131pt_BR
dc.rightsOpen Accessen
dc.subjectChlamydia trachomatispt_BR
dc.subjectEpidemiologyen
dc.subjectHuman papillomavirus 16en
dc.subjectPapilomavírus humano : HPVpt_BR
dc.subjectBiomarkersen
dc.subjectPharmacologicalen
dc.titleChlamydia trachomatis and human papillomavirus coinfection : association with p16ink4a and ki67 expression in biopsies of patients with pre-neoplastic and neoplastic lesionspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000772536pt_BR
dc.type.originNacionalpt_BR


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