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dc.contributor.authorJones, Marcus Herbertpt_BR
dc.contributor.authorCorso, Andréa Lúciapt_BR
dc.contributor.authorTepper, Robert S.pt_BR
dc.contributor.authorEdelweiss, Maria Isabel Albanopt_BR
dc.contributor.authorFriedrich, Lucianapt_BR
dc.contributor.authorPitrez, Paulo Marcio Condessapt_BR
dc.contributor.authorStein, Renato Tetelbompt_BR
dc.date.accessioned2014-06-21T02:07:10Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/96769pt_BR
dc.description.abstractObjective: To explore the relationship between prematurity, gender and chorioamnionitis as determinants of early life lung function in premature infants. Methods: Placenta and membranes were collected from preterm deliveries (,37 weeks gestational age) and evaluated for histological chorioamnionitis (HCA). Patients were followed and lung function was performed in the first year of life by Raised Volume-Rapid Thoracic Compression Technique. Results: Ninety-five infants (43 males) born prematurely (median gestational age 34.2 weeks) were recruited. HCA was detected in 66 (69%) of the placentas, and of these 55(58%) were scored HCA Grade 1, and 11(12%) HCA Grade 2. Infants exposed to HCA Grade 1 and Grade 2, when compared to those not exposed, presented significantly lower gestational ages, higher prevalence of RDS, clinical early-onset sepsis, and the use of supplemental oxygen more than 28 days. Infants exposed to HCA also had significantly lower maximal flows. There was a significant negative trend for z-scores of lung function in relation to levels of HCA; infants had lower maximal expiratory flows with increasing level of HCA. (p = 0.012 for FEF50, p = 0.014 for FEF25–75 and p = 0.32 for FEV0.5). Two-way ANOVA adjusted for length and gestational age indicated a significant interaction between sex and HCA in determining expiratory flows (p,0.01 for FEF50, FEF25–75 and p,0.05 for FEV0.5). Post-hoc comparisons revealed that female preterm infants exposed to HCA Grade 1 and Grade 2 had significant lower lung function than those not exposed, and this effect was not observed among males. Conclusions: Our findings show a sex-specific negative effect of prenatal inflammation on lung function of female preterm infants. This study confirms and expands knowledge upon the known association between chorioamnionitis and early life chronic lung disease.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofPloS one. San Francisco. Vol. 8, no. 12 (Dec. 2013), e81193, 6 p.pt_BR
dc.rightsOpen Accessen
dc.subjectCorioamnionitept_BR
dc.subjectComplacência pulmonarpt_BR
dc.subjectPulmãopt_BR
dc.subjectPrematuropt_BR
dc.titleChorioamnionitis and subsequent lung function in preterm infantspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000912227pt_BR
dc.type.originEstrangeiropt_BR


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