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Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents

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Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents

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Título Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents
Autor Konrad, Signorá Peres
Farah, Vera M.A.
Rodrigues, Bruno (Medicina)
Wichi, Rogério Brandão
Machado, Ubiratan Fabres
Lopes, Heno Ferreira
Schaan, Beatriz D'Agord
De Angelis, Kátia
Irigoyen, Maria Claudia Costa
Abstract OBJECTIVES: The aim of this study was to evaluate cardiovascular autonomic function in a rodent obesity model induced by monosodium glutamate injections during the first seven days of life. METHOD: The animals were assigned to control (control, n = 10) and monosodium glutamate (monosodium glutamate, n = 13) groups. Thirty-three weeks after birth, arterial and venous catheters were implanted for arterial pressure measurements, drug administration, and blood sampling. Baroreflex sensitivity was evaluated according to the tachycardic and bradycardic responses induced by sodium nitroprusside and phenylephrine infusion, respectively. Sympathetic and vagal effects were determined by administering methylatropine and propranolol. RESULTS: Body weight, Lee index, and epididymal white adipose tissue values were higher in the monosodium glutamate group in comparison to the control group. The monosodium glutamate-treated rats displayed insulin resistance, as shown by a reduced glucose/insulin index (-62.5%), an increased area under the curve of total insulin secretion during glucose overload (39.3%), and basal hyperinsulinemia. The mean arterial pressure values were higher in the monosodium glutamate rats, whereas heart rate variability (.7 times), bradycardic responses (.4 times), and vagal (,38%) and sympathetic effects (,36%) were reduced as compared to the control group. CONCLUSION: Our results suggest that obesity induced by neonatal monosodium glutamate treatment impairs cardiac autonomic function and most likely contributes to increased arterial pressure and insulin resistance.
Contido em Clinics. São Paulo. Vol. 67, n. 10 (out. 2012), p. 1209-1214
Assunto Glutamato de sódio
Obesidade
Pressão arterial
Resistência à insulina
[en] Arterial pressure
[en] Autonomic function
[en] Insulin resistance
[en] Monosodium glutamate
[en] Obesity
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/108649
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