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Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil

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Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil

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Título Phytochemical screening, antinociceptive and anti-inflammatory activities of Chrysopogon zizanioides essential oil
Autor Lima, Gabrielle Mendes
Quintans Júnior, Lucindo José
Thomazzi, Sara Maria
Almeida, Emyle Mayra Santana Alves
Melo, Mônica Santos de
Serafini, Mairim Russo
Cavalcanti, Sócrates Cabral de Holanda
Gelain, Daniel Pens
Santos, João Paulo Almeida dos
Blank, Arie Fitzgerald
Alves, Péricles Barreto
Oliveira Neta, Paulina Marques de
Lima, Julianeli Tolentino de
Rocha, Ricardo Fagundes da
Moreira, Jose Claudio Fonseca
Araujo, Adriano Antunes de Souza
Abstract Chrysopogon zizanioides (L.) Roberty, Poaceae, is a plant widely used in northeast Brazil in folk medicine for the treatment of various pathological conditions, including infl ammatory pain. The present study evaluated the antinociceptive and antiinfl ammatory effects of C. zizanioides essential oil (EO) in rodents. EO was further characterized by GC/MS. The major components of EO were identifi ed as khusimol (19.57%), E-isovalencenol (13.24%), α-vetivone (5.25%), β-vetivone (4.87%) and hydroxy-valencene (4.64%). Following intraperitoneal injection (i.p.), EO at 50 and 100 mg/kg signifi cantly reduced the number of writhes (51.9 and 64.9%, respectively) and the number of paw licks during phase 2 (56.7 and 86.2%, respectively) of a formalin model when compared to control group animals. However, EO-treated mice were ineffective at all doses in hot-plate and rota-rod tests. The EO inhibited the carrageenan-induced leukocyte migration to the peritoneal cavity in a dose-dependent manner (34.7, 35.4, and 62.5% at doses of 25, 50 and 100 mg/kg, respectively). In the paw edema test, the EO (100 mg/kg) inhibited all three phases of the edema equally well, suggesting that the EO has a non-selective inhibitory effect on the release or actions of these mediators. Our results suggest possible antinociceptive and antiinfl ammatory effects of the EO.
Contido em Revista brasileira de farmacognosia. Vol. 22, n. 2 (mar./abr. 2012), p. 443-450
Assunto Analgésicos
Anatherum muricatum
Anti-inflamatórios
Oleos essenciais
Plantas medicinais
[en] Anti-inflammatoryeffect
[en] antinociceptive effect
[en] Chrysopogon zizanioides
[en] essential oil
[en] phytochemical screening
[en] vetiver
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/108896
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