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Glucose and triglyceride excursions following a standardized meal in individuals with diabetes : ELSA-Brasil study

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Glucose and triglyceride excursions following a standardized meal in individuals with diabetes : ELSA-Brasil study

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Título Glucose and triglyceride excursions following a standardized meal in individuals with diabetes : ELSA-Brasil study
Autor Riboldi, Bárbara Pelicioli
Luft, Vivian Cristine
Castilhos, Cristina Dickie de
Cardoso, Letícia de Oliveira
Schmidt, Maria Inês
Barreto, Sandhi Maria
Diniz, Maria de Fátima Haueisen Sander
Matos, Sheila Maria Alvim de
Duncan, Bruce Bartholow
Abstract Objective: To assess glucose and triglyceride excursions 2 hours after the ingestion of a standardized meal and their associations with clinical characteristics and cardiovascular complications in individuals with diabetes. Research design and methods: Blood samples of 898 subjects with diabetes were collected at fasting and 2 hours after a meal containing 455 kcal, 14 g of saturated fat and 47 g of carbohydrates. Self-reported morbidity, socio-demographic characteristics and clinical measures were obtained by interview and exams performed at the baseline visit of the ELSA-Brasil cohort study. Results: Median (interquartile range, IQR) for fasting glucose was 150.5 (123–198) mg/dL and for fasting triglycerides 140 (103–199) mg/dL. The median excursion for glucose was 45 (15–76) mg/dL and for triglycerides 26 (11–45) mg/dL. In multiple linear regression, a greater glucose excursion was associated with higher glycated hemoglobin (10.7, 95% CI 9.1–12.3 mg/dL), duration of diabetes (4.5; 2.6–6.4 mg/dL, per 5 year increase), insulin use (44.4; 31.7–57.1 mg/dL), and age (6.1; 2.5–9.6 mg/dL, per 10 year increase); and with lower body mass index (−5.6; −8.4– -2.8 mg/dL, per 5 kg/m2 increase). In adjusted logistic regression models, a greater glucose excursion was marginally associated with the presence of cardiovascular comorbidities (coronary heart disease, myocardial infarction and angina) in those with obesity. Conclusions: A greater postprandial glycemic response to a small meal was positively associated with indicators of a decreased capacity for insulin secretion and negatively associated with obesity. No pattern of response was observed with a greater postprandial triglyceride excursion.
Contido em Cardiovascular diabetology. London. Vol. 14 (Feb. 13, 2015), p. 21, 9 p.
Assunto Carboidratos da dieta
Diabetes mellitus
Doenças cardiovasculares
Epidemiologia
Glicemia
Obesidade
Triglicerídeos
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/111680
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