Repositório Digital

A- A A+

Effects of bromocriptine on serum prolactin levels, pituitary weight and immunoreactive prolactin cells in estradiol-treated ovariectomized rats : an experimental model of estrogendependent hyperprolactinemia

.

Effects of bromocriptine on serum prolactin levels, pituitary weight and immunoreactive prolactin cells in estradiol-treated ovariectomized rats : an experimental model of estrogendependent hyperprolactinemia

Mostrar registro completo

Estatísticas

Título Effects of bromocriptine on serum prolactin levels, pituitary weight and immunoreactive prolactin cells in estradiol-treated ovariectomized rats : an experimental model of estrogendependent hyperprolactinemia
Autor Ribeiro, Maria Flavia Marques
Spritzer, Poli Mara
Coutinho, Ligia Maria Barbosa
Oliveira, Miriam da Costa
Pavanato, Maria Amalia
Brum, Ilma Simoni
Reis, Fernando Marcos dos
Abstract The present study was designed to assess the effects of bromocriptine, a dopamine agonist, on pituitary wet weight, number of immunoreactive prolactin cells and serum prolactin concentrations in estradioltreated rats. Ovariectomized Wistar rats were injected subcutaneously with sunflower oil vehicle or estradiol valerate (50 or 300 μg rat-1 week-1) for 2, 4 or 10 weeks. Bromocriptine (0.2 or 0.6 mg rat-1 day-1) was injected daily during the last 5 or 12 days of estrogen treatment. Data were compared with those obtained for intact control rats. Administration of both doses of estrogen increased serum prolactin levels. No difference in the number of prolactin cells in rats treated with 50 μg estradiol valerate was observed compared to intact adult animals. In contrast, rats treated with 300 μg estradiol valerate showed a significant increase in the number of prolactin cells (P<0.05). Therefore, the increase in serum prolactin levels observed in rats treated with 50 μg estradiol valerate, in the absence of morphological changes in the pituitary cells, suggests a “functional” estrogen-induced hyperprolactinemia. Bromocriptine decreased prolactin levels in all estrogen-treated rats. The administration of this drug to rats previously treated with 300 μg estradiol valerate also resulted in a significant decrease in pituitary weight and number of prolactin cells when compared to the group treated with estradiol alone. The general antiprolactinemic and antiproliferative pituitary effects of bromocriptine treatment reported here validate the experimental model of estrogen- induced hyperprolactinemic rats.
Contido em Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 30, n. 1 (jan. 1997), p. 113-117
Assunto Bromocriptina
Estradiol
Estrogênios
Prolactina
[en] Bromocriptine
[en] Estrogen
[en] Immunoreactive prolactin cells
[en] Pituitary growth
[en] Prolactin levels
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/129025
Arquivos Descrição Formato
000970884.pdf (189.2Kb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.