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QMix® irrigant reduces lipopolysacharide (LPS) levels in an in vitro model

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QMix® irrigant reduces lipopolysacharide (LPS) levels in an in vitro model

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Título QMix® irrigant reduces lipopolysacharide (LPS) levels in an in vitro model
Autor Gründling, Grasiela Sabrina Longhi
Melo, Tiago André Fontoura de
Montagner, Francisco
Scarparo, Roberta Kochenborger
Vier-Pelisser, Fabiana Vieira
Abstract The presence of endotoxin inside the root canal has been associated with periapical in vitro, the effect of QMix® and other three root canal irrigants in reducing the endotoxin content in root canals. Material and Methods: Root canals of single-rooted teeth were prepared. Samples were detoxified with Co-60 irradiations and inoculates with E. coli LPS (24 h, at 37°C). After that period, samples were divided into 4 groups, according to the irrigation solution tested: QMix®, 17% EDTA, 2% chlorhexidine solution (CHX), and 3% sodium hypochlorite (NaOCl). LPS quantification was determined by Limulus Amebocyte Lysate (LAL) assay. The initial counting of endotoxins for all samples, and the determination of LPS levels in non-contaminated teeth and in contaminated teeth exposed only to nonpyrogenic water, were used as controls. Results: QMix® reduced LPS levels, with a median value of 1.11 endoxins units (EU)/mL (p<0.001). NaOCl (25.50 EU/mL), chlorhexidine (44.10 EU/mL) and positive control group (26.80 EU/mL) samples had similar results. Higher levels were found with EDTA (176.00 EU/mL) when compared to positive control (p<0.001). There was no significant difference among EDTA, NaOCl and CHX groups. Negative control group (0.005 EU/mL) had statistically significant lower levels of endotoxins when compared to al test groups (p<0.001). Conclusion: QMix® decreased LPS levels when compared to the other groups (p<0.001). 3% NaOCl, 2% CHX and 17% EDTA were not able to significantly reduce the root canal endotoxins load
Contido em Journal of applied oral science. Bauru. Vol. 23, no. 4 (July/Aug. 2015), p. 431-435
Assunto Canais radiculares
Endodontia
Endotoxinas
[en] Chlorhexidine
[en] EDTA
[en] Endotoxins
[en] Sodium hypochlorite
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/130315
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