Navegação Ciências Biológicas por Título
Resultados 2716-2735 de 3025
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Tetrahydrobiopterin responsiveness of patients with phenylalanine hydroxylase deficiency
(2011) [Artigo de periódico]Objetivo: Identificar indivíduos responsivos à tetrahibrobiopterina (BH4) em uma amostra de pacientes brasileiros com hiperfenilalaninemia por deficiência de fenilalanina-hidroxilase (HPA-PAH). Métodos: Estudo intervencional, ... -
TGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil
(2012) [Artigo de periódico]We report a study of TGFA / Taq I polymorphisms and environmental factors in non-syndromic oral cleft in Southern Brazil. Nonsyndromic cleft case-parent triads were recruited to participate. Clinical data was collected ... -
The 100,000 most influential scientists rank : the underrepresentation of Brazilian women in academia
(2021) [Artigo de periódico]Despite the progress observed in recent years, women are still underrepresented in science worldwide, especially at top positions. Many factors contribute to women progressively leaving academia at different stages of their ... -
The 5 alpha-reductase type 1, but not type 2, gene is expressed in anagen hairs plucked from the vertex area of the scalp of hirsute women and normal individuals
(2003) [Artigo de periódico]The aim of the present study was to determine the expression of the genes for type 1 (SDR5A1) and type 2 (SDR5A2) 5α-reductase isoenzymes in scalp hairs plucked from 33 hirsute patients (20 with polycystic ovary syndrome ... -
The accuracy and robustness of plasma biomarker models for amyloid PET positivity
(2022) [Artigo de periódico]Background: Plasma biomarkers for Alzheimer’s disease (AD) have broad potential as screening tools in primary care and disease-modifying trials. Detecting elevated amyloid-β (Aβ) pathology to support trial recruitment or ... -
The age of brain organoids : tailoring cell identity and functionality for normal brain development and disease modeling
(2021) [Artigo de periódico]Over the past years, brain development has been investigated in rodent models, which were particularly relevant to establish the role of specific genes in this process. However, the cytoarchitectonic features, which determine ... -
The annual reproductive cycle of the snail Megalobulimus abbreviatus (Bequaert, 1948) (Gastropoda, pulmonata)
(2005) [Artigo de periódico]Variações morfológicas nos órgãos do sistema reprodutor dos gastrópodes pulmonados são observadas ao longo do ano e podem ser correlacionadas a fases de seu ciclo reprodutivo. A partir dessa observação, a massa dos órgãos ... -
The antiproliferative effect of indomethacin-loaded lipid-core nanocapsules in glioma cells is mediated by cell cycle regulation, differentiation, and inhibition of survival patheways
(2013) [Artigo de periódico]Despite recent advances in radiotherapy, chemotherapy, and surgical techniques, glioblastoma multiforme (GBM) prognosis remains dismal. There is an urgent need for new therapeutic strategies. Nanoparticles of biodegradable ... -
The application of static magnetic stimulation reduces survival of SH-SY5Y neuroblastoma cells
(2023) [Artigo de periódico]Background/Aim: Central nervous system cancer is still a major public health issue. The effectiveness of treatments is limited and varies depending on the severity of disease. Therefore, there is a demand for the development ... -
The association of age-related and off-target retention with longitudinal quantification of [18F]MK6240 tau PET in target regions
(2023) [Artigo de periódico]6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F] MK6240) tau PET tracer quantifies the brain tau neurofibrillary tangle load in Alzheimer disease. The aims of our study were to test the stability ... -
The beliefs of mothers in southern Brazil regarding risk-factors associated with congenital abnormalities
(2004) [Artigo de periódico]We describes a study in which conventional wisdom about congenital malformations was investigated, the two main objectives being to list mothers’ ideas by comparing six well-known causes of congenital abnormalities (ingestion ... -
The binomial center-periphery and the evaluation of science based on indicators
(2019) [Artigo de periódico]The evaluation of science based on bibliometric indicators can generate greater visibility for the science of the peripheries or build and sustain peripheral situations in the scientific system. This article reflects on ... -
The black flies (Diptera: Simuliidae) from Santa Catarina, Brazil
(2011) [Artigo de periódico]The Simuliidae fauna from the Santa Catarina state, Brazil, was documented, based primarily on specimens deposited in the collections of the Instituto Oswaldo Cruz, Brazil and the La Plata Museum, Argentina. The results ... -
The brain decade in debate : I. Neurobiology of learning and memory
(2000) [Artigo de periódico]This article is a transcription of an electronic symposium in which some active researchers were invited by the Brazilian Society for Neuroscience and Behavior (SBNeC) to discuss the last decade’s advances in neurobiology ... -
The brazilian contribution to attention-deficit/hyperactivity disorder molecular genetics in children and adolescents
(2012) [Artigo de periódico]Attention-Deficit/Hyperactivity Disorder (ADHD) is a common psychiatric condition of children worldwide. This disorder is defined by a combination of symptoms of inattention and hyperactivity/impulsivity. Diagnosis is based ... -
The brazilian hereditary cancer network : historical aspects and challenges for clinical cancer genetics in the public health care system in Brazil
(2016) [Artigo de periódico]Resumo não disponível -
The brief methylprednisolone administration is crucial to mitigate cardiac dysfunction after myocardial infarction
(2021) [Artigo de periódico]Acute myocardial infarction (AMI) is one of the major causes of heart failure and mortality. Glucocorticoids administration post-infarction has long been proposed, but it has shown conflicting results so far. This controversy ... -
The calcium goes meow : effects of ions and glycosylation on Fel d 1, the major cat allergen
(2015) [Artigo de periódico]The major cat allergen, Fel d 1, is a structurally complex protein with two N-glycosylation sites that may be filled by different glycoforms. In addition, the protein contains three putative Ca2+ binding sites. Since the ... -
The Central Sensitization Inventory validated and adapted for a brazilian population : psychometric properties and its relationship with brain-derived neurotrophic factor
(2017) [Artigo de periódico]Objectives: The primary aim was to assess the psychometric properties (including internal consistency, construct validity, reproducibility, and factor structure) of the Central Sensitization Inventory (CSI), adapted and ...