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Behavioral deficits in sepsis-surviving rats induced by cecal ligation and perforation

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Behavioral deficits in sepsis-surviving rats induced by cecal ligation and perforation

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Título Behavioral deficits in sepsis-surviving rats induced by cecal ligation and perforation
Autor Barichello, Tatiana
Martins, Márcio Rodrigo
Reinke, Adalisa
Machado, Roberta Altino
Constantino, Larissa de Souza
Valvassori, Samira da Silva
Moreira, Jose Claudio Fonseca
Quevedo, João Luciano de
Dal Pizzol, Felipe
Abstract Sepsis and its complications are the leading causes of mortality in intensive care units, accounting for 10-50% of deaths. Intensive care unit survivors present long-term cognitive impairment, including alterations in memory, attention, concentration, and/or global loss of cognitive function. In the present study, we investigated behavioral alterations in sepsis-surviving rats. One hundred and ten male Wistar rats (3-4 months, 250-300 g) were submitted to cecal ligation and puncture (CLP), and 44 were submitted to sham operation. Forty-four rats (40%) survived after CLP, and all sham-operated animals survived and were used as control. Twenty animals of each group were used in the object recognition task (10 in short-term memory and 10 in long-term memory), 12 in the plus-maze test and 12 in the forced swimming test. Ten days after surgery, the animals were submitted individually to an object recognition task, plus-maze and forced swimming tests. A significant impairment of short- and long-term recognition memory was observed in the sepsis group (recognition index 0.75 vs 0.55 and 0.74 vs 0.51 for short- and long-term memory, respectively (P < 0.05). In the elevated plus-maze test no difference was observed between groups in any of the parameters assessed. In addition, sepsis survivors presented an increase in immobility time in the forced swimming test (180 vs 233 s, P < 0.05), suggesting the presence of depressive-like symptoms in these animals after recovery from sepsis. The present results demonstrated that rats surviving exposure to CLP, a classical sepsis model, presented recognition memory impairment and depressive-like symptoms but not anxietylike behavior.
Contido em Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 40, no. 6 (june 2007), p. 831-837
Assunto Cognição
Memória
Sepse
Sistema nervoso central
[en] Cecal ligation and puncture
[en] Cognitive impairment
[en] Forced swimming test
[en] Plus-maze test
[en] Recognition memory
[en] Sepsis survivors
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21215
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