Repositório Digital

A- A A+

Atherosclerosis and acute arterial thrombosis in rabbits : a model using balloon desendothelization without dietary intervention

.

Atherosclerosis and acute arterial thrombosis in rabbits : a model using balloon desendothelization without dietary intervention

Mostrar registro completo

Estatísticas

Título Atherosclerosis and acute arterial thrombosis in rabbits : a model using balloon desendothelization without dietary intervention
Autor Picon, Paulo Dornelles
Gonçalves, Sandro Cadaval
Wainstein, Marco Vugman
Costa, Andry Fiterman
Mengarda, Claudia Vieira
Machado, R.P.
Berlim, Gustavo Levacov
Edelweiss, Marcia
Edelweiss, Maria Isabel Albano
Ribeiro, Jorge Pinto
Abstract Acute thrombosis can be induced in rabbits by a triggering protocol using Russell’s viper venom and histamine given after 8 months of a 1% cholesterol diet and balloon desendothelization. In the present study, we tested the hypothesis that aortic desendothelization performed 4 months before the triggering protocol without a high cholesterol diet is a highly effective and less expensive way of producing arterial atherosclerosis and thrombosis. Nineteen male New Zealand white rabbits on a normal diet were studied. The control group (N = 9) received no intervention during the 4-month observation period, while the other group (N = 10) was submitted to aortic balloon desendothelization using a 4F Fogarty catheter. At the end of this period, all animals were killed 48 h after receiving the first dose of the triggering treatment. Eight of 10 rabbits (80%) in the balloon-trauma group presented platelet-rich arterial thrombosis while none of the animals in the control group had thrombus formation (P<0.01). Thus, this model, using balloon desendothelization without dietary manipulation, induces arterial atherosclerosis and thrombosis and may provide possibilities to test new therapeutic approaches.
Contido em Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 30, n. 3 (mar. 1997), p. 415-417
Assunto Angioplastia
Aterosclerose
Coelhos
Endotélio vascular
Trombose coronária
[en] Coronary artery disease
[en] Endothelium
[en] Histamine
[en] Russell's viper venom
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/21222
Arquivos Descrição Formato
000652300.pdf (207.2Kb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.