Repositório Digital

A- A A+

Expression of mdr isoforms in mice during estrous cycle and under hormone stimulation

.

Expression of mdr isoforms in mice during estrous cycle and under hormone stimulation

Mostrar registro completo

Estatísticas

Título Expression of mdr isoforms in mice during estrous cycle and under hormone stimulation
Autor Schiengold, Marion
Schwantes, Lavinia
Ribeiro, Maria Flavia Marques
Lothhammer, Nivia
Gonzalez, Tatiana Pereira
Chies, Jose Artur Bogo
Nardi, Nance Beyer
Abstract The multidrug resistance (MDR) phenotype is associated with the expression of P-glycoprotein (Pgp), coded by the multigenic mdr family. Mice present the isoforms mdr1 and mdr3, which are responsible for multidrug resistance, and mdr2, that is involved in the transport of phospholipids. mdr1 expression has more recently been associated also with the secretion of steroid hormones. This work presents an RT-PCR analysis of the expression of mdr isoforms, in several organs of mice during different phases of the estrous cycle. Additionally, females were ovariectomized, submitted to different hormone treatments, and their uterus was analyzed for the expression of mdr isoforms. The results show that in the adrenal gland and ovaries mdr1 is the main isoform during proestrus, and that progesterone or a combination of progesterone and estrogen induce the expression of all mdr isoforms in the uterus of ovariectomized females. We suggest that the functions of mdr1 and mdr3 are overlapping, that mdr3 may be the more efficient isoform in the detoxification function, and that mdr1 may be more closely related to the secretion of steroid hormones.
Contido em Genetics and molecular biology. Ribeirão Preto. Vol. 29, n. 4 (Dec. 2006), p. 755-761
Assunto Drogas
Glândula adrenal
Glicoproteina P
[en] Adrenal gland
[en] Multidrug resistance
[en] Ovaries
[en] Steroids
[en] Uterus
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/23393
Arquivos Descrição Formato
000566846.pdf (74.29Kb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.