Repositório Digital

A- A A+

Evolutionary plasticity determination by orthologous groups distribution

.

Evolutionary plasticity determination by orthologous groups distribution

Mostrar registro completo

Estatísticas

Título Evolutionary plasticity determination by orthologous groups distribution
Autor Dalmolin, Rodrigo Juliani Siqueira
Castro, Mauro Antônio Alves
Rybarczyk Filho, José Luiz
Souza, Luís Henrique Trentin de
Almeida, Rita Maria Cunha de
Moreira, Jose Claudio Fonseca
Abstract Background: Genetic plasticity may be understood as the ability of a functional gene network to tolerate alterations in its components or structure. Usually, the studies involving gene modifications in the course of the evolution are concerned to nucleotide sequence alterations in closely related species. However, the analysis of large scale data about the distribution of gene families in non-exclusively closely related species can provide insights on how plastic or how conserved a given gene family is. Here, we analyze the abundance and diversity of all Eukaryotic Clusters of Orthologous Groups (KOG) present in STRING database, resulting in a total of 4,850 KOGs. This dataset comprises 481,421 proteins distributed among 55 eukaryotes. Results: We propose an index to evaluate the evolutionary plasticity and conservation of an orthologous group based on its abundance and diversity across eukaryotes. To further KOG plasticity analysis, we estimate the evolutionary distance average among all proteins which take part in the same orthologous group. As a result, we found a strong correlation between the evolutionary distance average and the proposed evolutionary plasticity index. Additionally, we found low evolutionary plasticity in Saccharomyces cerevisiae genes associated with inviability and Mus musculus genes associated with early lethality. At last, we plot the evolutionary plasticity value in different gene networks from yeast and humans. As a result, it was possible to discriminate among higher and lower plastic areas of the gene networks analyzed. Conclusions: The distribution of gene families brings valuable information on evolutionary plasticity which might be related with genetic plasticity. Accordingly, it is possible to discriminate among conserved and plastic orthologous groups by evaluating their abundance and diversity across eukaryotes.
Contido em Biology direct. London. Vol. 6, no. 22 (17 May 2011), 18 p.
Assunto Biofísica
Bioinformática
Filogenia
Genes
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/30951
Arquivos Descrição Formato
000782094.pdf (1.065Mb) Texto completo (inglês) Adobe PDF Visualizar/abrir

Este item está licenciado na Creative Commons License

Este item aparece na(s) seguinte(s) coleção(ões)


Mostrar registro completo

Percorrer



  • O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia.
    Projeto gráfico elaborado pelo Caixola - Clube de Criação Fabico/UFRGS Powered by DSpace software, Version 1.8.1.