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Prevalence of antibodies against measles, mumps, and rubella before and after vaccination of school-age children with three different triple combined viral vaccines, Rio Grande do Sul, Brazil, 1996

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Prevalence of antibodies against measles, mumps, and rubella before and after vaccination of school-age children with three different triple combined viral vaccines, Rio Grande do Sul, Brazil, 1996

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Título Prevalence of antibodies against measles, mumps, and rubella before and after vaccination of school-age children with three different triple combined viral vaccines, Rio Grande do Sul, Brazil, 1996
Outro título Prevalencia de anticuerpos contra sarampión, paperas y rubéola en niños en edad escolar antes y después de la vacunación con tres vacunas triples antivirales combinadas diferentes, Rio Grande do Sul, Brasil, 1996
Autor Santos, Boaventura Antonio dos
Straliotto, Selir Maria
Siqueira, Marilda M.
Ranieri, Tani Schilling
Bercini, Marilina
Schermann, Maria Tereza
Wagner, Mario Bernardes
Silveira, Themis Reverbel da
Resumen Objetivo. Se evaluó la seroprevalencia para sarampión, paperas y rubéola en niños en edad escolar (6–12 años) antes y después de la administración de tres vacunas triples antivirales combinadas. Métodos. Se colectaron 692 muestras de sangre antes de la vacunación y 636 muestras entre 21 y 30 días después de la vacunación a niños de dos escuelas municipales de Rio Grande do Sul, Brasil, durante 1996. Se investigó la seropositividad de anticuerpos de la clase IgG mediante un ensayo de inmunoadsorción enzimática tipo ELISA (sarampión y paperas con Enzygnost [Behring, Marburgo, Alemania] y rubéola con Rubenostika [Organon Teknica, Boxtel, Países Bajos]). Las vacunas comparadas fueron: a) E-Zagreb, L-Zagreb y Wistar RA 27/3 (Tresivac); b) Moraten, J-Lynn y Wistar RA 27/3 (M-M-R II); y c) Schwarz, Urabe AM-9 y Wistar RA 27/3 (Trimovax). Resultados. Antes de la vacunación, 79,2% (intervalo de confianza [IC] 95%: 76,0 a 82,2) de las muestras fueron positivas para sarampión, 69,4% (IC 95%: 65,8 a 72,8) para paperas y 55,4% (IC 95%: 51,6 a 59,2) para rubéola. Después de la vacunación con las vacunas A, B y C, la seropositividad fue de 100%, 99,5% y 100%, respectivamente para sarampión; de 99,5%, 94,5% y 92,0% para paperas; y de 92,6%, 92,3% y 88,6% para rubéola. Conclusiones. Alrededor de un quinto (20,8%) de los escolares que pudieron haber sido vacunados contra el sarampión a los 9 meses de edad tenían niveles de anticuerpos insuficientes para protegerlos. En la muestra de escolares sin vacunación previa contra paperas y rubéola se encontró una alta proporción de niños susceptibles. Todas las vacunas fueron inmunogénicas, pero la vacuna A produjo una tasa de seroconversión de 99,5% para el componente de paperas, significativamente mayor que la de las otras dos vacunas (P < 0,01).
Abstract Objective. We evaluated the seroprevalence for measles, mumps, and rubella in school-age children (6–12 years old) before and after the administration of three triple combined viral vaccines. Methods. In two municipal schools of Rio Grande do Sul, Brazil, 692 blood samples were collected before vaccination and 636 samples 21 to 30 days after vaccination during 1996. IgG antibody seropositivity was investigated by enzyme-linked immunosorbent assay (measles and mumps with Enzygnost [Behring, Marburg, Germany]; rubella with Rubenostika [Organon Teknica, Boxtel, the Netherlands]). The vaccines compared were: A: E-Zagreb, L-Zagreb, and Wistar RA 27/3 (Tresivac); B: Moraten, J-Lynn, and Wistar RA 27/3 (M-M-R II); and C: Schwarz, Urabe AM-9, and Wistar RA 27/3 (Trimovax). Results. Before vaccination, 79.2% [95% confidence interval (CI) = 76.0%–82.2%] of the samples were positive for measles, 69.4% (95% CI = 65.8%–72.8%) for mumps, and 55.4% (95% CI = 51.6%–59.2%) for rubella. After vaccination with the A, B, and C vaccines, seropositivity was 100.0%, 99.5%, and 100.0%, respectively for measles; 99.5%, 94.5%, and 92.0% for mumps; and 92.6%, 91.3%, and 88.6% for rubella. Conclusions. About one-fifth (20.8%) of the schoolchildren who could have been vaccinated against measles at age 9 months had levels of antibodies insufficient for protection. In the sample of schoolchildren without previous vaccination against mumps and rubella, high proportions of susceptible levels were found. All vaccines were immunogenic, but vaccine A yielded a seroconversion rate of 99.5% for the mumps component, which was significantly higher than the other two vaccines (P < 0.01).
Contido em Revista panamericana de salud pública. Washington. Vol. 20, no. 5 (Nov. 2006), p. 299-306
Assunto Anticorpos
Anticorpos antivirais
Rio Grande do Sul
Vacinação
Vacina contra sarampo-caxumba-rubéola
[en] Antibodies, viral
[en] Measles-mumps-rubella vaccine
[en] Vaccination
[es] Anticuerpos virales
[es] Brasil
[es] Paperas
[es] Rubéola
[es] Sarampión
[es] Vacunación
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/66412
Arquivos Descrição Formato
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