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Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc

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Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc

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Título Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with hplc
Autor Malesuik, Marcelo Donadel
Paim, Clésio Soldateli
Steppe, Martin
Schapoval, Elfrides Eva Scherman
Abstract A rapid, economical, reproducible, and simple direct spectrophotometric method was developed and validated for the assay of nitazoxanide in pharmaceutical formulations. Nitazoxanide concentration was estimated in water at 345 nm and pH 4.5. The method was suitable and validated for specificity, linearity, precision, and accuracy. There was no interference of the excipients in the determination of the active pharmaceutical ingredient. The proposed method was successfully applied in the determination of nitazoxanide in coated tablets and in powders for oral suspension. This method was compared to a previously developed and validated method for liquid chromatography to the same drug. There was no significative difference between these methods for nitazoxanide quantitation.
Contido em Química nova. São Paulo. Vol. 33, n. 3 (2010), p. 739-742
Assunto Nitazoxanida
Validação : Métodos de análise de fármacos
[en] Method validation
[en] Nitazoxanide
[en] UV-spectrophotometry
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/72886
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