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Susceptibility to DNA damage in workers occupationally exposed to pesticides, to tannery chemicals and to coal dust during mining

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Susceptibility to DNA damage in workers occupationally exposed to pesticides, to tannery chemicals and to coal dust during mining

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Título Susceptibility to DNA damage in workers occupationally exposed to pesticides, to tannery chemicals and to coal dust during mining
Autor Kvitko, Katia
Bandinelli, Eliane
Henriques, Joao Antonio Pegas
Heuser, Vanina D.
Rohr, Paula
Silva, Fernanda Rabaioli da
Schneider, Nayê Balzan
Fernandes, Simone Pereira
Ancines, Camile Alves
Silva, Juliana da
Abstract Our mutagenesis group has been studying with important economic drivers of our state, such as agriculture, the footwear and leather industry and open-cast coal mining. Working conditions in these sectors have potentially harmful to humans. The aim of these studies is to determine the health risk of workers by biomonitoring subjects exposed to genotoxic agents. The main results of our studies with vineyard farmers we observed a high rate of MN and DNA damage in individuals exposed to pesticides (p < 0.001). In addition, some effects of genetic polymorphisms in the modulation of MN results were observed in this group. Tobacco farmers were also evaluated at different crop times. The results showed a significant increase in the Damage index and frequency in tobacco farmers compared to the non-exposed group, for all crop times. The results for footwear and tannery workers showed a significant increase in the mean ID for the solvent-based adhesive (p < 0.001) group in comparison to the water-based adhesive group and control (p < 0.05). For open-cast coal mine workers, the EBCyt indicated a significant increase in nuclear bud frequency and cytokinetic defects in the exposed group compared to the non-exposed group (p < 0.0001). We were able to associate specific genetic susceptibility with each type of exposure and with the non-use or improper use of personal protection equipment and diet adequacy. These results show how important the continuous education of exposed workers is to minimizing the effect of the occupational exposure and the risk of disease associated with the work.
Contido em Genetics and molecular biology. Vol. 35, n. 4 supl (Dec. 2012), p. 1060-1068
Assunto Carvão
Curtume
Dano do DNA
Exposição ocupacional
Pesticida
[en] coal dust
[en] Comet assay
[en] micronucleus test
[en] occupational exposure
[en] pesticide
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/87953
Arquivos Descrição Formato
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