|Título||Ki-67 antigen overexpression is associated with the metaplasia-adenocarcinoma sequence in Barrett’s esophagus
Volkweis, Bernardo Silveira
Gurski, Richard Ricachenevsky
Pretto, Guilherme Gonçalves
Mazzini, Guilherme da Silva
Edelweiss, Maria Isabel Albano
|Abstract||Introduction. The objective of this study was to evaluate Ki-67 antigen expression in patients with Barrett’s esophagus and esophageal adenocarcinoma and to assess its correlation with the metaplasia-esophageal adenocarcinoma progression. Methods. Using immunohistochemistry we evaluated the Ki-67 index in patients with Barrett’s esophagus, esophageal adenocarcinoma, and controls.We included patients with endoscopically visible columnar mucosa of the distal esophagus (whose biopsies revealed specialized intestinal-type metaplasia), patients with esophageal and esophagogastric tumors types I and II, and patients with histologically normal gastric mucosa (control). Results. In the 57 patients studied there were no statistically significant differences between the groups with respect to age or race. Patients with cancer were predominantly men. The Ki-67 index averaged 10 ± 4% in patients with normal gastric mucosa (n = 17), 21 ± 15% in patients with Barrett’s esophagus (n = 21), and 38 ± 16% in patients with cancer (n = 19). Ki-67 expression was significantly different between all groups (P < 0.05). There was a strong linear correlation between Ki-67 expression and the metaplasia-adenocarcinoma sequence (P < 0.01). In patients with cancer, Ki-67 was not associated with clinical or surgical staging. Conclusions. Ki-67 antigen has increased expression along the metaplasiaadenocarcinoma sequence. There is a strong linear correlation between Ki-67 proliferative activity and Barrett’s carcinogenesis.
|Contido em||Gastroenterology Research and Practice. Cairo. Vol. 2012 (2012), ID 639748,  p.
Esôfago de Barrett
|Tipo||Artigo de periódico
|000856047.pdf (1.974Mb)||Texto completo (inglês)||Adobe PDF||Visualizar/abrir|
Este item está licenciado na Creative Commons License