Mostrar registro simples

dc.contributor.authorKeiserman, Brielept_BR
dc.contributor.authorRonchetti, Maria Ritapt_BR
dc.contributor.authorMonticielo, Odirlei Andrépt_BR
dc.contributor.authorKeiserman, Mauro Waldemarpt_BR
dc.contributor.authorStaub, Henrique Luizpt_BR
dc.date.accessioned2014-06-21T02:07:20Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn1874-3129pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/96787pt_BR
dc.description.abstractPrevious reports proposed that the IgM anti-dsDNA antibody is protective for lupus nephritis. In this crosssectional study, we aimed to compare clinical features of systemic lupus erythematosus (SLE) patients positive for IgG anti-dsDNA alone with those presenting both IgG and IgM anti-dsDNA. Anti-dsDNA antibodies, urinary examination and complement levels were assessed in the day of appointment. IgG and IgM anti-dsDNA antibodies were detected by indirect immunofluorescence. Fifty-eight SLE patients (93.1% female, 81% European-derived, mean age 42.8±14.7 years, mean duration of disease 10.9±8 years) positive for IgG anti-dsDNA entered the study. Of those, 15 were also positive for the IgM anti-dsDNA isotype. The group with both isotypes showed significant less frequency of active nephritis (sediment changes and proteinuria) when compared to patients with IgG anti-dsDNA alone (6.7% versus 34.9%, p=0.046). These data suggest a nephroprotective role for IgM anti-dsDNA and a distinct biologic behavior for this isotype in SLE.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofOpen rheumatology journal. Hilversum. Vol. 7 (Nov. 2013), p. 101-104pt_BR
dc.rightsOpen Accessen
dc.subjectLupus eritematoso sistêmicopt_BR
dc.subjectSystemic lupus erythematosusen
dc.subjectLupus nephritisen
dc.subjectNefrite lúpicapt_BR
dc.subjectIgG and IgM anti-dsDNA antibodiesen
dc.titleConcomitance of IgM and IgG anti-dsDNA antibodies does not appear to associate to active lupus nephritispt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000914511pt_BR
dc.type.originEstrangeiropt_BR


Thumbnail
   

Este item está licenciado na Creative Commons License

Mostrar registro simples