Concomitance of IgM and IgG anti-dsDNA antibodies does not appear to associate to active lupus nephritis
dc.contributor.author | Keiserman, Briele | pt_BR |
dc.contributor.author | Ronchetti, Maria Rita | pt_BR |
dc.contributor.author | Monticielo, Odirlei André | pt_BR |
dc.contributor.author | Keiserman, Mauro Waldemar | pt_BR |
dc.contributor.author | Staub, Henrique Luiz | pt_BR |
dc.date.accessioned | 2014-06-21T02:07:20Z | pt_BR |
dc.date.issued | 2013 | pt_BR |
dc.identifier.issn | 1874-3129 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/96787 | pt_BR |
dc.description.abstract | Previous reports proposed that the IgM anti-dsDNA antibody is protective for lupus nephritis. In this crosssectional study, we aimed to compare clinical features of systemic lupus erythematosus (SLE) patients positive for IgG anti-dsDNA alone with those presenting both IgG and IgM anti-dsDNA. Anti-dsDNA antibodies, urinary examination and complement levels were assessed in the day of appointment. IgG and IgM anti-dsDNA antibodies were detected by indirect immunofluorescence. Fifty-eight SLE patients (93.1% female, 81% European-derived, mean age 42.8±14.7 years, mean duration of disease 10.9±8 years) positive for IgG anti-dsDNA entered the study. Of those, 15 were also positive for the IgM anti-dsDNA isotype. The group with both isotypes showed significant less frequency of active nephritis (sediment changes and proteinuria) when compared to patients with IgG anti-dsDNA alone (6.7% versus 34.9%, p=0.046). These data suggest a nephroprotective role for IgM anti-dsDNA and a distinct biologic behavior for this isotype in SLE. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Open rheumatology journal. Hilversum. Vol. 7 (Nov. 2013), p. 101-104 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Lupus eritematoso sistêmico | pt_BR |
dc.subject | Systemic lupus erythematosus | en |
dc.subject | Lupus nephritis | en |
dc.subject | Nefrite lúpica | pt_BR |
dc.subject | IgG and IgM anti-dsDNA antibodies | en |
dc.title | Concomitance of IgM and IgG anti-dsDNA antibodies does not appear to associate to active lupus nephritis | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000914511 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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