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The effect of antihypertensive agents on sleep apnea : protocol for a randomized controlled trial

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The effect of antihypertensive agents on sleep apnea : protocol for a randomized controlled trial

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Título The effect of antihypertensive agents on sleep apnea : protocol for a randomized controlled trial
Autor Cichelero, Fábio Tremea
Martinez, Denis
Fuchs, Sandra Cristina Pereira Costa
Gus, Miguel
Moreira, Leila Beltrami
Fuchs, Flávio Danni
Abstract Background: Obstructive sleep apnea (OSA) and hypertension are well-known cardiovascular risk factors. Their control could reduce the burden of heart disease across populations. Several drugs are used to control hypertension, but the only consistently effective treatment of OSA is continuous positive airway pressure. The identification of a drug capable of improving OSA and hypertension simultaneously would provide a novel approach in the treatment of both diseases. Methods/Design: This is a randomized double-blind clinical trial, comparing the use of chlorthalidone with amiloride versus amlodipine as a first drug option in patients older than 40 years of age with stage I hypertension (140 to 159/90 to 99 mmHg) and moderate OSA (15 to 30 apneas/hour of sleep). The primary outcomes are the variation of the number of apneas per hour and blood pressure measured by ambulatory blood pressure monitoring. The secondary outcomes are adverse events, somnolence scale (Epworth), ventilatory parameters and C reactive protein levels. The follow-up will last 8 weeks. There will be 29 participants per group. The project has been approved by the ethics committee of our institution. Discussion: The role of fluid retention in OSA has been known for several decades. The use of diuretics are well established in treating hypertension but have never been appropriately tested for sleep apnea. As well as testing the efficacy of these drugs, this study will help to understand the mechanisms that link hypertension and sleep apnea and their treatment.
Contido em Trials. [London]. Vol. 15, p. 1-5 (Jan. 2, 2014)
Assunto Amlodipino
Apnéia do sono tipo obstrutiva
Clortalidona
Diuréticos
Hipertensão
[en] Amlodipine
[en] Chlorthalidone
[en] Diuretics
[en] Hypertension
[en] Sleep apnea
[en] Treatment
Origem Estrangeiro
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/106994
Arquivos Descrição Formato
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