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Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population

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Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population

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Título Androgen receptor CAG polymorphism and the risk of benign prostatic hyperplasia in a Brazilian population
Autor Biolchi, Vanderlei
Silva Neto, Brasil
Koff, Walter Jose
Brum, Ilma Simoni
Abstract Benign prostatic hyperplasia (BPH) is a very frequent age-related proliferative abnormality in men. Polymorphic CAG repeat in the androgen receptor (AR) can alter transactivation of androgen-responsive genes and potentially infl uence BPH risk. We investigated the association between CAG repeat length and risk of BPH in a case-control study of a Brazilian population. We evaluated 214 patients; 126 with BPH and 88 healthy controls. DNA was extracted from peripheral leucocytes and the AR gene was analyzed using fragment analysis. Hazard ratio (HR) and 95% confi dence interval were estimated using logistic regression models. Mean CAG length was not different between patients with BPH and controls. The CAG repeat length was examined as a categorical variable (CAG ≤ 21 vs. CAG > 21 and CAG ≤ 22 vs. CAG > 22) and did not differ between the control vs. the BPH group. We found no evidence for an association between AR CAG repeat length in BPH risk in a population-based sample of Brazilians
Contido em International brazilian journal of urology. Rio de Janeiro, RJ. Vol. 38, no. 3 (May/June 2012), p. 373-379
Assunto Hiperplasia prostática
Polimorfismo genético
Receptores androgênicos
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/119119
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