• Anxiolytic properties of compounds that counteract oxidative stress, neuroinflammation, and glutamatergic dysfunction : a review 

      Santos, Patrícia; Herrmann, Ana Paula; Elisabetsky, Elaine; Piato, Angelo Luis Stapassoli (2019) [Artigo de periódico]
      Objective: Anxiety disorders are highly prevalent and the efficacy of the available anxiolytic drugs is less than desired. Adverse effects also compromise patient quality of life and adherence to treatment. Accumulating ...
    • Melatonin prevents hyperglycemia in a model of sleep apnea 

      Kaminski, Renata Schenkel Rivera; Martinez, Denis; Fagundes, Micheli; Martins, Emerson Ferreira; Montanari, Carolina Caruccio; Rosa, Darlan Pase da; Fiori, Cintia Zappe; Marroni, Norma Anair Possa (2015) [Artigo de periódico]
      Objective: Obstructive sleep apnea is a common disorder associated with aging and obesity. Apneas cause repeated arousals, intermittent hypoxia, and oxidative stress. Changes in glucolipidic profile occur in apnea patients, ...
    • N-acetylcysteine improves antitumoural response of Interferon alpha by NF-kB downregulation in liver cancer cells 

      Kretzmann, Nelson Alexandre; Chiela, Eduardo Cremonese Filippi; Matte, Ursula da Silveira; Marroni, Norma Anair Possa; Marroni, Claudio Augusto (2012) [Artigo de periódico]
      Background: Liver cancer is one of the most common malignancies in the world and at the moment, there is no drug intervention effective for the treatment of liver tumours. Investigate the effect of N-acetylcysteine (NAC), ...
    • N-acetylcysteine+nimesulide : an association strategy aiming to prevent nimesulide-induced hepatotoxicity 

      Elias, Amanda Godoi; Silva, Julia Spanhol da; Klein, Rafaela Luiza; Amaral, Francieli Ubirajara India; Arbo, Marcelo Dutra; Conte, Fernanda Mocellin; Garcia, Solange Cristina; Dallegrave, Eliane; Martins, Janaine Ramos; Bertol, Charise Dallazem; Setim, Diorges Henrique; Motta, Adriana Costa da; Barcelos, Rômulo Pillon; Rossato, Luciana Grazziotin (2020) [Artigo de periódico]
      Introduction: Nimesulide is a potent anti-inflammatory with rapid and long-lasting effects, but also with a high risk of hepatotoxicity. Objective: This work aimed to prevent nimesulide-induced hepatotoxicity through the ...
    • N-acetylcysteine protects against motor, optomotor and morphological deficits induced by 6-OHDA in zebrafish larvae 

      Benvenutti, Radharani; Marcon, Matheus Felipe; Reis, Carlos Guilherme Rosa; Nery, Laura Roesler; Miguel, Camila; Herrmann, Ana Paula; Vianna, Monica Ryff Moreira Roca; Piato, Angelo Luis Stapassoli (2018) [Artigo de periódico]
      Background: Parkinson’s disease (PD) is the second most common neurodegenerative disorder. In addition to its highly debilitating motor symptoms, non-motor symptoms may precede their motor counterparts by many years, which ...