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Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer

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Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer

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Título Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer
Autor López, R.V.M.
Zago, Marco Antonio
Eluf-Neto, Jose
Curado, Maria Paula
Daudt, Alexander Welaussen
Silva Junior, W.A. da
Zanette, D.L.
Levi, J. E.
Carvalho, M.B. de
Kowalski, Luiz Paulo
Abrahão, M.
Góis Filho, J.F. de
Boffetta, Paolo
Wünsch Filho, Victor
Abstract The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6%). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95%CI = 0.15-1.81) and T/T (HR = 0.22; 95%CI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 +114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95%CI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95%CI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95%CI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95%CI = 0.26-1.78) and larynx cancer (HR = 0.93; 95%CI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise.
Contido em Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Vol. 44, n. 10 (out. 2011), p. 1006-1012
Assunto Consumo de bebidas alcoolicas
Estudos de casos
Neoplasias de cabeça e pescoço
Tabaco
[en] Alcohol
[en] Cancer prognosis
[en] Head and neck cancer
[en] Interleukin
[en] Smoking
[en] Survival analysis
Origem Nacional
Tipo Artigo de periódico
URI http://hdl.handle.net/10183/37319
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